I found out my zofran causes constipation. And I've been taking it pretty much every day for a long time. Makes sense why I'm more clogged up then a Dutch shoe factory right now. 3 Colace and a glass of Mirolax did nothing but give me a headache and a slight stomach ache. I'm not overly concerned, then again I am one to downplay this kind of stuff. My mom says this isn't a good situation to be in. Idk. I can't be without zofran. It works as well as valium.