During the short period I took Zyprexa, I also gained a lot of weight and fast. After going off of it I lost that weight on more weight friendly meds. I had also gained a larger amount of weight on other weight unfriendly meds (Depakote and Invega mix the worst). After being taken off of them I lost about 40 lbs in six months, but I did diet and exercise. It didn't just fly away with no effort and it was a healthy gradual loss. Not rapid. If you exercise and eat a healthy amount, I can't imagine that you wouldn't lose the Zyprexa weight over time.