I have lost over 40 pounds since I reduced the 625 mgs of Seroquel that was prescribed to me about 13 years ago. I was taking a tablet and a half before that and gained about 25 pounds. Well it started taking a toll on me. I reduced it to 300 mgs before bed. I was still getting undesired side affectd so I started breaking it in half and took that before bed. I started to loose weight continially. Now my weight is close to what it was before I took seroquel. I don't recommend doing this unless your telling your med manager what your doing. I struggle with depression, anxiety, OCD, and panic disorder. Brokenfriend (Hugs)