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Old Jun 28, 2023, 07:38 AM
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MrAbbott MrAbbott is offline
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Member Since: Jul 2022
Location: Spain
Posts: 124
Quote:
Originally Posted by Tart Cherry Jam View Post
I do not think that it is a fair statement that as a class, mood stabilizers have fewer/milder side effects than antipsychotics. The only mood stabilizer with a relatively benign side effects profile is Lamotrigine and it will not do a thing for psychosis. All the others have very serious side effects. A better comparison is to see on an individual basis what each drug (not each class of drugs) produces in you and go from there.

MrAbbott, it is possible for many people to treat bipolar with antipsychotics alone. For some people it may mean taking two antipsychotics. For some it may mean just one, called monotherapy. In terms of FDA approval in the US, Zyprexa is FDA approved as a monotherapy for bipolar and is extremely effective but has a horrible metabolic syndrome side effect. Then there are antipsychotics that are not (yet) FDA approved as bipolar monotherapy but are used as such off label (outside of the official approval). From a Medline (PubMed) search:

Olanzapine, risperidone and quetiapine have been shown to be effective for manic episodes both as monotherapy and in combination with other agents such as lithium and divalproex. Divalproex is valproic acid. Since Invega is a newer cousin of Risperidone, I am pretty sure it can be effective as a monotherapy but you need to give it a try to figure out if this is true.
for you.

How is your bloodwork? Both lithium and valproic acid therapy have to be accompanied by regular blood tests.

Thank you for all this info, Tart. I've actually looked for AP monotherapy but found so little info I have nothing to show my pdoc, I'll keep at it. I guess that if I end up in psych ward, they'll also pump either lithium or valproic into my system without checking my preferences, they are like that. I'll try speaking with my doc, or maybe waiting a year to see if valproic is able to stop mania and psychosis much better for me than lithium has had. My limit is 1 year, then I go psychotic.

My bloodwork is not worrying at the moment, the thyroid gland was the most affected, starting with hypothyroidism, but slowly changing to valproichas corrected that. I take omega 3 supplements and my cholesterol has improved but it could be better.

Thanks so much for all of this. I like to know stuff and be able to choose. Stay well.
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Dx: bipolar type 1 with psychosis + some OCD

Invega 3mg
Depakine 800mg
Plenur 400mg
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