It can help a lot when paired with Venlafaxine, but not any psychiatrist will prescribe this for you, as it can cause serotonin syndrome. But in my case, I have needed Venlafaxine + Mirtazapine to help with my depression a lot, a lot, a lot. Anyway, obviously don't try that without talking to your Dr. but I feel like mirtazapine has helped a lot on its own too. But combined with the venlafaxine it is great. (Meaning that it works).