@Queenie1234 welcome to MSF. I am sorry your friend is hurting from depression. Isolation from people is a usual reaction when one is suffering from depression.
The short answer is until your friend reaches out for help like psych meds then there is not much you can do except be a good friend. Listen when they talk and be patient when they clam up. People can still hold down a job and be depressed even if that seems difficult.
If you feel that you are struggling also with some mental health issues and it is possible, a therapist can help us cope with our own situation and respond appropriately to others.
Hope you get the support you are looking for. @CANDC
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