Hi. Can anyone tell me if some combinations work perfect together and not at all as monotherapy? In the past i took lamictal and effexor for depression but without effexor lamictal was nothing. Now i take risperidone and recently added valproate which in the past i took it as monotherapy at low doses and nothing happens. Now i take max dose with optimal therapeutic levels with risperidone low dose. Is there a chance that things can change for the best? Also a couple days ago doc removed my antidepressant because i started having hypomania and valproate didnt do anything to protect from hypo or mania because i just started it. So i dont know if antidepressant made things worse or i should wait for valproate to kick in and take again the antidepressant. Im confused. So tell me opinions and advices. I hope valproate with an atypical antipsychotic like risperidone will make the difference. Thank you!