I've taken Seroquel XR also sometimes with Seroquel IR for probably 12 years or so. Most of these years I've been on higher doses, mostly between 500 to 700 mg. Yes, my sleep schedules have been wonky, at times. Initially, it made me painfully drowsy, but that has varied over the years, depending on the dosages or where my moods were at. This past year or so, on top of about 600 mg XR, I was also put on 50 IR. The XR didn't knock me out early enough. I'd take all of the XR at like 7 pm, and would not be able to get to sleep until 2 am. Then, I'd get a nice 8 hours of sleep, but getting up at 10 am is not ideal, even without having a job. The extra 50 mg IR did help a little for a while, but now I'm still up until 2 am, or so. Sometimes I start to get very drowsy at around 10 pm, but if I don't make a huge effort to fall asleep, I then get a second wind.

Unless I'm getting some level of manic, even when I wake up in the morning I wake up feeling slightly "drunk" from the Seroquel. However, once I get my butt out of bed, the drunk feeling fades in about 10 minutes.

Only when very manic have I seemed a morning person. All other times, mornings have been difficult. Or very difficult. I remember when I still worked I'd have such irritable rage in the morning that I'd throw stuff against the wall and scream. That's not the case anymore, luckily.

In the past, when traveling abroad, I'd skip my Seroquel. Over time, I learned that was not the best move for me. Better to take it. Very often when I skip it (I rarely forget it completely), some hours after the normal time I become manic-like. I can more easily get away with forgetting my morning meds than the evening ones.