They gave me benadryl IP once to calm me down because I couldn't stop pacing while waiting for a pdoc on the weekend (of course). They gave me several doses before realizing that it was making me much more agitated and that I just don't process benadryl normally. When I was agitated my suicidal symptoms went way up and my mood swings were endless and out of control. They kept trying to find things for me to keep busy and eventually put me on `1:1 for a shift or two to try to distract me into sitting still. Then I finally got a huge dose of gabapentin, slept for a long time and felt much less scary. No more benadryl for me.