I think I was generally on 50 mg of sertraline and went up to 100 at one point, but noticed more side effects. I'm really sensitive to meds. It was a long time ago that I tried buspirone, so I have no idea what dose that was. I don't know if it did much for me, but I know it helps some people. I think trazodone just completely knocked me out, though I know it's often used for sleep. (It made me stay sleepy during the day, which doesn't work for editing!)