They're both very different.

I noticed almost no notable changes to my personality with vraylar, perhaps a bit less excitable. Also threw up on 3mg for a week or two but for whatever reason was fine on 6.

Seroquel zonked me out more. When I was taking 200 at night my days were a bit nicer. I was docile and calm. Not bad, maybe slightly good, but did nothing for dysthymia. Sort of was bored all the time.

And 800 Seroquel throughout the day in the hospital, similar feeling but less active. Sort of felt like a pig in sht, just "fine,".