Yeah, I haven't tried that drug. I think I am a pretty median weight person. If anything, the olanzapine helped me reach a more normal BMI; before the Zyprexa, I was borderline underweight. Now I'm about 185-190lbs at about 6'3", which puts my BMI right around 25.
Anyway, it would seem to me that Lybalvi would be rather expensive. I'm not too sure how much samidorphan would cost on its own, however. But $324.09 for a thirty-day supply (and this was back in the late nineties) seems to be very lucrative for Eli Lilly. I was surprised that it was more expensive than Clozaril.
I surmise the reason for this is that in retrospect, besides Seroquel, olanzapine was the newest antipsychotic.