Benadaryl can cause agitation. I was IP once over the weekend and they wanted to wait unil the until pdoc was there on Monday to start doing anything dramatic with my meds so they put me on benadryl. I kept getting more and more agitated and finally the nurse realized that it was happening after a dose of bendadrryl. So I spent a lot of time in the shower trying to relax and had bedtime PRNs early. The next day I had a 1:1 to try to keep me calmer. It was great. But now I know that I do not take benadryl.