I take Synthroid when I wake up in the middle of the night. I ran it by my endocrinologist and she said it is OK. As long as you take it on an empty stomach, do not eat anything for at least 30 minutes after you have taken it, and do not take any drugs or supplements for 4 hours after you have taken it, it is ok.

She is a new doctor on my treatment team. Before I started with her, I had not known about the 4 hr rule.

Regarding Bizi's question, I carry a small bottle of Geodon in my purse. If I happen to be eating out, I take Geodon from my purse. If I eat in, I take Geodon from another bottle that is on my dining table. I do remember if I have taken it. If I didn't remember, I would open a thread with myself in my email and would message myself right after taking it. This way you would not take a double dose.