I had profound cognitive problems from Topamax as well as kidney stones. A medicine similar to it, Zonegran, never used to cause much problems until last year when I got a 5 mm kidney stone stuck in my ureter and got metabolic acidosis. I tapered off of it as safely as possible. I was on up to 400 mg of Topamax before I just threw the towel in. I hope you find something that works for you.