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mikrw33's Avatar
Member Since Jan 2013
Location: Madison, Alabama, USA
Posts: 40
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Default Mar 08, 2024 at 03:54 AM
There's one additional amphetamine-based stimulant, Evekeo (amphetamine sulfate). IME, it's not the greatest stimulant, but it's even "milder" than Adderall.

There are some non-stimulant wakefulness promoting agents, such as modafinil (Provigil), armodafinil (Nuvigil), Sunosi (solriamfetol), and Wakix (pitolisant). Modafinil and armodafinil both do work on increasing dopamine levels, as well as being a D2 partial agonist, but their main mechanism of action for promoting wakefulness is through increasing orexin, a wakefulness-promoting neuropeptide. Sunosi actually may as well be a stimulant since it's a norepinephrine-dopamine reuptake inhibitor. Wakix is a histamine H3 inverse agonist, causing enhanced release of histamine in the brain. There are also actually sedatives specifically for narcolepsy, Xywav and Xyrem. They're both oxybate, but Xyrem is just sodium oxybate, whereas Xyrem is a combination of calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate in an attempt to decrease the amount of sodium from the medicine and improve the taste (Xyrem doesn't taste so great, and while Xywav doesn't taste good per se and has an artificial sweetener in it, it doesn't taste "good" per se... lol). It's basically prescription GHB which consolidates REM sleep and improves next-day hypersomnia.

Perhaps with hopefully one of these meds, you could be able to treat your narcolepsy without the need of a mood stabilizer or antipsychotic.

Diagnoses: Tourette's Disorder, OCD, ADHD-PI, Bipolar I Disorder, Borderline Personality Disorder, Anxiety Disorder Unspecified

Dyanavel XR 15 mg 30 mg/day
Lamictal 300 mg/day
Cymbalta 90 mg/day
Lunesta 3 mg/night
Dayvigo 10 mg/night
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Thanks for this!