Quote:
Originally Posted by mar dhea
Antidep I've been taking for years [tried both generic & namebrand] don't seem to be doing much anymore. Wellbutrin is the name. Bupropion. Extended release. 300mg once a day.
Would like to hear from any long-term users of this med who switched to something they found to work better.
|
You have just a little more room to go up with bupropion. You can go up to 450 mg/day safely. Beyond that increases the risk of seizures without any additional benefit.
Also, you could ask your pdoc about adding sertraline (Zoloft). It's a great adjunct to bupropion because it's a CYP2B6 inhibitor, which inhibits bupropion's metabolism to hydroxybupropion, which is primarily a norepinephrine reuptake inhibitor. Adding sertraline balances out the dopamine reuptake inhibition relevant to its norepinephrine reuptake inhibition, plus adding serotonin reuptake inhibition to the mix. Also, sertraline is a mild dopamine reuptake inhibitor to boot.