Weed increases the effects of alcohol a lot, you'll get the spins and weed will make you freak out about that.

As with most drugs, I find it's best to just have an evening where you've got nothing to do, have some food stored in the fridge or similar you like, D in the bed, few puffs, see how you feel after 10 minutes, maybe few more puffs, then prbly eat or do some fun thing