I had a rare bad reaction to clozaril. Extreme water retention, swelling, edema in my ankles, respiratory problems.... my psychiatrist said he'd never seen anything like it! And he's pretty much retired right now and July is his last month. Not to mention the DROOLING. I had a DROOL towel at night. Lol. And all the blood draws... ugh. It worked well though. Made me nice and fat and jolly. But was overall a miserable experience for me. Had to abruptly stop it, went through withdrawal, and THAT was a miserable experience... the anxiety! Omg!

Obviously everyone is different though. And like I said, I had a very, VERY rare bad reaction to it. So I think it's worth a shot, if you're running out of options.

What APs have you all tried?

Seroquel?
Prolixin?
Abilify?
Haldol?
Latuda?

I'm trying to think of any others I've tried... Abilify gave me akathisia, Haldol worked great for seven years but then started giving me muscle rigidity and stopped working, and prolixin just worked me up and made me anxious and I hated it. It was like an evil Haldol. I was on latuda for like a day and just remember it making me feel really high. Right now I'm on seroquel, which is working great (no delusions or hallucinations), and 50mg of loxapine, but I know you were just on loxapine and it didn't work out for you.

Anyway, meds are frustrating!

Has your akathisia gone away?