It sounds like there are people in your world who don't want to be as close to you, as you want to be to them. I've been through that, and it's hurtful. Maybe, in the past, they did seem to be interested in a closer relationship. Then, for reasons of their own, they have retreated to a greater distance. It happened to me with an ex-roommate. We were friends, shared an apartment and did stuff together. Eventually, I found a place of my own and she got married. Pretty soon, I seldom heard from her. Then I moved far away. After a while, I mailed her a letter, saying I would be in her area and would like to visit her. She never responded, which caused me some hurt feelings.
When someone doesn't respond to us, I think that's a message that they want more distance from us. They don't want to be as close, as we want to be. It's a form of rejection. That stings. But I think we just have to accept their decision. I think it's unwise to invest a lot in anyone who is not investing in us.