My problem is dropping them on the floor or in the couch when i empty them out of the little box and then not being able to find the missing one. So then i have to borrow one from another day box. But no, i never mess up my doses. Too high or too low could probably unalive me. I always think thats my "get out of jail free" card, that or pneunomia, but then i am very scrupulous.