Your wife is acting like a petulant child having a tantrum when she doesn't get her way. Your wife is using abuse tactics to get her way - the silent treatment is an abuse tactic.

I would not put up with or tolerate this kind of treatment and behavior. Your response to get the medication the next day was perfectly reasonable. Clearly your wife does not know the meaning of compromise and give and take - she is a taker and you are the giver in this relationship.

If you're considering separating and throwing in the towel on the marriage, I don't blame you. That kind of behavior doesn't change. Your wife is who she is right now.

GIven her stance on you helping with the business, your exhaustion from it all, and her stance that you must help, well, this is a one-way relationship, not a two-way relationship based on fairness, equality, and respect.

I would honestly separate if I were you.