I also experienced severe restlessness and akathisia with seroquel, I believe I was on 600mg at the time. the akathisia felt like torture. I didn't feel angry just horrible feeling restless to the point I was having thoughts of Sui. Never experienced anything like that on any other of the myriad of meds and APs I've been on and hope to never again cause it scared me.

I could be wrong in my memory but I do recall it causing racing heart before it kicks in