Akathesia is an uncomfortable aggravation, for sure. However, I can think of two conditions that make it seem pleasant. One is the charlie horse which is when your thigh muscles tighten beyond your control and any movement or attempt to relax them only makes it worse. Much worse. Niacin flushing is another extremely uncomfortable sensation. High doses of Niacin can treat high cholesterol, but your body must gradually adjust to the high doses. If you miss a dose and resume without incrementing, or exceed your tolerance, you may experience flushing, which is a mad itching that occurs all over your body. It will induce a panic and make you want to jump out of a window.