Dpselfhelp.com has conducted polls on what has caused the majority of DP/DR among those who participate in the forum. The vast majority report it was caused by cannabis. Most relate they had a panic reaction and a couple of days afterward, they shifted into DP/DR. I have a theory that a powerful psychological stimulus such as an anxiety attack from cannabis can activate the gene regulation process, turning a genetic process on or off, causing DP/DR. I shared my history of DP/DR with a coworker. Her teenage son subsequently took some of the synthetic cannabis which was legally sold at convenience stores. That stuff was like 50x more powerful than the cannabis you could buy on the street. He never came down. He's been on the couch ever since and Duke hospital says they can do nothing for him. You still hear about someone taking a gummy and staying in orbit. It's all very sad.