I have Sleep Apnea and control it with CPAP therapy.

I've been taking 50mg Nuvigil daily for years for daytime sleepiness. (It's almost nothing -- the usual starting dose is 150mg.)

I'm wondering why two 50mg pills is way more effective than a single 150mg pill. They're made by different labs in India. What do you think it's due to?

1. The 50mg pills are produced by a "better" lab. (My theory)
2. The optimum dose for me at this time really is 100mg, and side effects from the higher dose are outweighing the benefits. (Pharmacist's theory)
3. Other

I haven't spoken to the doctor yet -- I wanted to give the 150mg dose more time. Here's more background...

At my latest office visit, I complained about fatigue and brain fog, so the doctor suggested increasing the dose. The pills come in 50, 150, 200+, so we collectively agreed to go right up to 150 without titrating.

I still had several pills of the 50mg left, so I started taking two at once at the usual time. I was impressed by how effective it was! This lasted for a few days, until I ran out and switched to the 150mg pills.

The triple dose was much less effective than the double dose.