@Mountaindewed

"Generally, aspirin and Tylenol (acetaminophen) can be taken together, especially for pain relief, as they work through different mechanisms and don't have significant interactions. However, it's crucial to be aware of potential risks and consult a healthcare professional before combining them, especially if you have pre-existing conditions or are taking other medications. "

The Bayer stuff does contain extra caffeine to make it work better and the tylenol PM might cancel that out.

I have no idea how any of this interacts with your other meds and that's obviously hugely important.