I feel like I've tried every anti-depressant out there with little to no effect. I have been either mildly depressed to majorly depressed for over 15 years. I have worked with some great therapists, but that to has not had much effect. I've been on effexor, prozac, wellbutrin, lexapro, adderall, ritalin, provigil, etc. Of course not at the same time, but none seemed to help. I'm so desperate to feel better and not sleep all the time, but nothing seems to help. Am I just immune to anti-depressants or will they ever find something that will actually make a difference? After all these years between seeing psychologists and medical doctors, I ready to just give up