Well, that blows my theory right out of the water! Poor kid! I do however agree with the puberty comment. I think between the age of 13 to 18 and 1/2 I smiled twice. My Mom and grandparents worried about me a lot. I still stayed involved in sports it was the only thing I enjoyed. They just considered me to be miserable not depressed. Your son situation sounds worse then just a miserable teen. I really hope he's feeling better soon. Is there such a thing as an undercovered therapists, someone who will befriend your child. Just a thought, I don't know much about therapy.
Again the best of luck to you.