Mary Alice - 100mg of Zoloft™ (sertraline) is a fairly high starting dose, unless you are switching from another antidepressant. There can be reasons to start at higher doses; side effects (eg. which are just effects of the drug that we don't want, at the time) can be used instead of resorting to another drug. For instance, Zoloft's initial side effects include sedation and an anti-anxiety effect, which may be why your pdoc started you at the 100mg.

I'd double check with your pdoc and see if he really meant for you to start at that dose. It can't hurt, and it shows that you are involved in your treatment and recovery. ... or you could get your pharmacist to contact your pdoc to confirm that dose.

I am sure that there are other reasons to start at a high dose, I just can't remember them at the moment. I hope that this is of some help. - Cam