In the past I had been on both, not at the same time, unfortunately neither had much impact on my depression, I didn't notice any unusual weight gain, I did notice though, that prozac made me feel less fatigued than effexor,I also was on the extended release type.
I had also been prescribed (not all at the same time) zoloft,wellbutrin, and celexa, celexa out of all of those helped.
It does stink, that most AD's contribute to weight gain, eh?
Like just what a depressed person wants, is to gain weight
I can tell you when I was on mood stabilizer, depakote, I gained lots of weight, remeron also made me gain weight and feel like a zomby so the doc changed my meds. things are so much better now, Lamictal agrees with my system so finally one has been perfect for me, no weight gain and no fatigue, just the natural sleepiness not drug induced, yay!
Another good thing I am on half the dose I started with 2 years ago, another, yay!
Oops! Sorry I got to rambling on, I guess I am chatty today

Take care, I hope all works out for you


DE