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Anti-depressants make you gain weight because some of them (Paxil, Remeron, Serzone and the tricyclics like Elavil) block the H1 histamine receptor. By looking at which antidepressants affect the H1 receptor you can directly predict the chances of weight gain. H1 receptor blockade stimulates appetite but doesn't affect your metabolism. Prozac, Celexa, Lexapro, Effexor, Wellbutrin don't affect H1 much thus no weight gain.
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