I take my Synthroid in the middle of the night when I get up to pee :-) if you wake at all during the night. That gets it out of the way of most things.

My asthma meds were bothering my tummy but now that I'm eating properly (enough fiber) and losing weight the asthma is easing too so I don't have to use the meds as often so the GERD and other GI problems have gone away.