I've been on Cymbalta for several months, after trying 3 other AD's. They all sent me into varying degrees of hypomania, but the Cymbalta doesn't. In fact, it makes me kind of tired, so I take it at night. I was eating everything in sight for the first 2 weeks, but that has leveled off. No other side effects for me, and it's literally been a lifesaver, chasing away the black clouds in my head.......