I take both at night. The trazodone for me is entirely to help my sleep--it helps me go to bed and stay asleep. I love it so much, if I could meet whoever invented it, I would totally jump into his arms and plant a kiss on his cheek! I went from sleeping 2-5 hours with several wakeups throughout the night to 8 solid hours, every night, with only occasional nightmares. It's wonderful!

I'm not sure about the Zoloft. I started that two years ago in the midst of a depression, and I'm not depressed anymore. My doctor keeps me on it because he says it will keep my anxiety down. I know I used to feel much, much worse, so this combo works just fine for me.

I hope you find the right combo.