Thanks for sharing, desertnurse. I definitely believe in healthy living. Diet, exercise, sleep etc. can all make a huge difference in our health (and can affect our biochemistry too). One of the things that helped me tremendously with my depression was working hard to conquer my sleep problems. I believe a person's attitude and life outlook can also play a role in altering their biochemistry (for the better and for the worse). Not everything can work for everyone, and a lot of things can help a little. Sometimes, it can all add up to help a lot. One of the biggest helps for me with depression and PTSD has been psychotherapy. We have worked a lot on healing wounds and processing trauma. We are now moving into a sort of phase that is very forward looking, where I identify my career, relationship, artistic, spiritual, etc. goals and how I will work toward them. Having something to look forward to in life is very helpful to me. Hope that my life could be better has helped so much. It probably sounds trivial, but I think regaining hope is what has helped me the most.