Funny, it works fine for me.
Didn't make me as sick as Effexor did (!!!)
Cymbalta/Wellbutrin combo is managing my depression very nicely.

The only thing I notice is that I KNOW when I miss a dose, so I imagine the withdrawls could get nasty.
And I know I'm not like most people...Nothing else has worked for me except MAOIs. And compared to those, this is a cake-walk.