Yes. After trying Paxil, Zoloft, Prozac, Lexapro and others, I found Effexor XR which worked for me. Unfortunately, it raised my blood pressure to a dangerous level and I had to switch to Cymbalta. While Cymbalta also worked well for me, it stopped working after about 1.5 years. I tried Zoloft, then Prozac. Finally I've found Pristiq which is working very well for me. I also take Trazodone which affords me a decent night's sleep for a change. I hadn't had a good night's sleep in maybe 20 years. I was falling asleep when the sun rose before but now I can get to sleep before midnight. They haven't eliminated my symptoms but I do feel much better.