I have gained something like 45 pounds since going on Depakote. (I'd spent a few years losing 60 just prior and was holding steady.) I knew it would happen. I remember the first day I took it- right before I put it in my mouth- I knew I was making a decision. Well, I'm glad my brain is better than it used to be, but still.... Its a choice. My Pdoc and I had discussed switching me to meds that are more weight-neutral, but she really thinks I react almost perfectly on this- give or take. If I forget 2 or 3 pills in a row, all bets are off! I made a promise to my dad that I would always take them and he has promised to not drink. So far, so good.