Gee, sorry to say this, but there is probably not a lot you can do if she isn't being compliant with her meds., by her not taking her mood stabilizers, her mania is going to take over, and depending what variation, Bipolar-II, Bipolar-I which also can have different variants, the disorder is not a "black or white" thing, there are grey areas.
She is 48 (so am I), telling a woman at her age and being manic, will continue to do what she wants, regardless of the outcome, if she is not taking her meds as prescribed.
When a person is feeling the euphoria that often comes from manic episodes, they try to make it last, by stopping meds. and pdoc appts. Sure, it is fun while it lasts but sooner or later trouble follows, crashing, and then sneeky "old" depression slithers in.
Due to all the Patient Privacy Acts, you'd probably not be allowed to talk to her pdoc, but if you can, explain how your friend is acting, and is not taking her meds as prescribed, there may be some suggestions given by him or her, or even one of the nurses.
I am so sorry that you and her are going through this hell at the present time, I send you good wishes for better days.
Please take care,
DE <font color="purple"> </font>