Hi Mark,

I also take 375mg of Effexor XR. I take 2 Red Capsules and a Peach Capsule every morning, along with the rest of my morning cocktail. I was on 37.5mg and gradual increase to 375mg. I dont think I blame this med for weight gain, only I am on so many meds dont know which ones to blame for what.

I noticed at the beginning, depression less only my panic and agoraphobia not helped by it that much. I think it does help some. They have talked of adding a ssri in addition to the Effexor XR only not done so yet. I know about being sick when miss a dose. I don't know if I will ever be able to stop taking it. Sorry did not have much advice other than I feel alot the same as you descriped. You are the first person I have contact with on the extremely high dose as myself. Peace-Chris