Larry - As a toxicologist, I thought that you might be interested in this website. I'm not sure if you know about Dave Flockhart's website on CYP-450 drug interactions. I found this amazing site about 6 or 7 years ago and have watched it develop into the ultimate resource for cytochrome interactions. Dr. Flockhart is the Director of Clinical Pharmacology at Indiana University. For awhile the site was restricted, but they've opened it up to everyone, again.

The website is very user friendly, and has a lot of "extras" that aren't readily apparent. Dr. Flockhart has broken the interactions into substrates, inhibitors, and inducers listed sequentially under each isoenzyme. If you click on individual drugs you will find the references proving the interaction. He also includes information on the genetics of the cytochrome system, also including references. The search function is different, and kinda cool.

The good doctor has also condensed the main table into another table which lists only Clinically Relevent CYP-450 Interactions which does save time when I use it at work.

If you are feeling particularily affluent, you can order the table in a pocket card format . They use to be free, but now you have to buy at least 10 cards at $3.00/card (there is a volume discount). I know that if I still worked in the system, I'd be taking up a collection so that all the clinicians would have one sticking out of their pocket. The card is update twice a year, but the table is now so complete (as compared with 5 years ago) that you'd only need to order one every other year. Actually, just print off the clinically relevant table and tack it up in the office. I just slid mine into a plastic sleeve and tack it up on the corkboard in my office.

I hope that you are able to use this. - Cam