I was on Topamax for awhile. It worked nicely when I first started on it, then after a month or so I would get really depressed so my pdoc would raise the dosage again. It would work for a short period then not. We did this until I was at the maximum dosage. Then I really went down hill. It was awful so I told my pdoc that I had to get off it. Now I am feeling really good. I am on wellbutrin and remeron. Don't know if this helps just thought I would share.
Zen