I don't have any personal experience with antidepressants, but what I have heard is that anger and irritability can occur while transitioning into taking medication. Low self esteem is usually a consequence of depression itself.

As for communication in relationships, it's the BIGGEST problem. It can be attributed to any number of things, but bear in mind that depression can also lead people to withdraw into themselves, which includes not communicating with anyone (even loved ones). If you want to get inside, you'll really have to put some effort in. If it's someone you care about a lot, trust me, it's really worth the effort. Hope this helped, feel free to ask if you have any more questions

~TheDeliciousDish