In a recent thread about SSRI induced weight gain you stated that in your clinical experience the weight gain brought on by SSRI's such as Lexapro is usually irreversible. Did you mean that as long as a person STAYS on that drug they find it very difficult, if not impossible to lose the weight, or did you mean that even after they discontinue that particular med they are unable to lose that weight? As in, the mechanism of action that caused the weight gain has become permanent? I really don't see how this could be, but am completely freaking out about this as I stopped taking Lexapro 2 months ago (took it for 3 1/2 months) and did experience the increase in appetite that you talked about. While on it, I had no desire to exercise, ate junk food like crazy and as a result gained quite a bit of weight.

I'm trying to lose now, doing all the 'right' things, all the things that worked for me in the past (as recently as less than one year ago) but I'm having a hell of a time these past few weeks. I've lost maybe 1 pound since I've been weighing in (almost 2 weeks.)

I took Effexor XR a few years ago and couldn't lose while on it, but once I stopped and started eating right the weight came off. So, by irreversible, did you mean that as long as you are taking the drug, but not after d/c-ing it? With my current situation I'm beginning to wonder. Thanks in advance for responding!