Mineral balance, the net effect of intake (e.g. diet) and outflow (e.g. urine content), is one factor to consider. If you're letting more go than you're taking in, your body will become depleted. Usually, your body will take whatever steps it can to retain potassium, if the diet is deficient.....but there's a limit to that ability.

Then, you have to consider that a normal intake might still be associated with a low potassium level (hypokalemia), via some kind of illness or dysfuntional state (e.g. kidney disease, bulimia) that increases loss of this mineral.

See: http://lpi.oregonstate.edu/infocente...als/potassium/

Down near the bottom are tables of some drugs that affect blood levels of potassium.

Wellbutrin, as far as I know, does not directly or indirectly affect potassium level. However, low potassium may increase the perception of adverse effects from Wellbutrin (that's possible, I suppose), without being classed as an interaction.

Lar