Avoid drinking alcohol. It can increase some of the side effects of Lyrica. Lyrica can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by Lyrica. Tell your doctor if you regularly use any of these other medicines.