Well depending on when you take it will be the real decideing factor if you will like it at first or not. Usually the doseage in the morning starts off low and your doc will bring it up as your body gets used to it. I am currently taking 100 mg in the morning and 700 mg at night. It does wonders for me combined with the Lithium that I take. I have worked up to that high of a dosage and I have discussed it with my doc and we both feel that I am at a very productive level (that was last Mon.). I will soon be taken off seroquel and lithium alltogether now that I am pregnant. But don't let some people discourage you in here. They will holler don't take it, because it didn't work for them. It is up to your doctor and YOU to decide if it will work for you. Remember that it can take up to 3 weeks for your body to get aclamated with the meds your on.