I am on Effexor Xr, have been for about 4 1/2 months. I lost 18 pounds in the begining. I have had pretty good results and feel much better then I did even though I still have my down days. However, since feeling better, makes my appetite back to normal so I have gained my weight back. But the upside is, I'm feeling better then i was before I started it. I have heard that there are bad withdraws with Effexor. I wouldnt know cause I'm still on it. Different meds react differently for everyone. If you read the side effects, it says weight loss is a side effect. Thats my story and I'm stickin to it. LOL