I went on lamictal and crestor the same time. However, i got a rash and we decided to stop the lamictal just in case. I've never had the up swings just highly irritated mood or low depressive states. My mania comes in the form of high anxiety and low depression. I take abilify, prozac, klonopin, traodone. I seem to be doing well except for my menstral cycle when i feel often depressed.